Regulation of renin‐angiotensin system via the release of bioactive peptides including angiotensin‐converting enzyme inhibitory peptides,72 improvement of lipid profile or blood cholesterol via increased lipolysis and reduction of lipoprotein lipase activity,73 improving the blood pressure (BP),74 reducing PAI‐1 levels, and decreasing the plasma glucose levels,14 are the probable mechanisms probiotics employ to improve hypertensive disorders. This evidence concerns the gene ACE and hypertensive disorder.