This finding is further corroborated by the fact that in a transgenic fly constitutively expressing a TDP-43 aggregation inducer (ALS-like model), the main physiological decrease in TDP-43 during fly ageing (∼4-fold at 10 days) coincides with the onset of the locomotion defect in this model. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.