For example, as shown in Fig. 7, the continuous capture of newly synthesized TDP-43 by inclusions, which has been observed in most ALS patients (Neumann et al., 2006), will only be pathological if the age-related reduction in TDP-43 is equal to or less than the capacity of the inclusion to capture this protein, which results in loss of its nuclear function. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.