It has been reported to ameliorate concanavalin-A-induced mouse experimental fulminant hepatitis and increased heme oxygenase-1 (HO-1) expression through mitogen-activated protein kinase/nuclear factor erythroid 2-related 2 (MAPK/Nrf2) antioxidant pathway in RAW264 macrophage cell lines (Zhao et al., 2015). This evidence concerns the gene HMOX1 and Fulminant hepatitis.