AKT1 and acute lymphoblastic leukemia: Previous studies have suggested that the capacity of B-lineage lymphocytes and ALLs to tolerate oncogenic signaling is limited (Grundschober et al., 2014; Schwartzman et al., 2017; Shojaee et al., 2015), and AKT hyperactivation was shown to inhibit precursor B-ALL development (Shojaee et al., 2016).