And experiments using Reh cells (including both Ctrl and RASmt cells) in bone marrow xenograft mice showed that chemically inhibiting mTOR signaling by low-dose AZD-8055 could significantly promote the in vivo growth of RASmt cells (Figure 6E), but the promoting effect disappeared when we used high-dose AZD-8055 which further decreased the phosphorylation level of AKT in RASmt cells (Figure S6), suggesting a proper mTOR inhibition is important to rescue the growth defects of KRAS-G12D ALL cells. Here, KRAS is linked to acute lymphoblastic leukemia.