To determine which specific amino acid(s) may contributed to the observed compromised growth of KRAS-G12D mutant B-ALL cells, we profiled the intracellular levels of amino acids in Reh cells cultured in normal medium and found that RASmt cells had significantly reduced levels of arginine (Arg), methionine (Met), serine (Ser), cysteine (Cys), and glutamine (Gln) compared to control cells (Figure 3A). Here, KRAS is linked to acute lymphoblastic leukemia.