Immune mediation plays an important role in the development of T1DM especially the immune response centered on T lymphocytes [7], where B cells act as antigen-presenting cells presenting antigens to CD4+ and CD8+ T lymphocytes, producing antibodies that activate T lymphocytes and trigger or exacerbate islet autoimmunity [16, 17]. Here, CD4 is linked to type 1 diabetes mellitus.