RBP4 and Insulin resistance: The adipose cells play a regulatory role in the development of insulin resistance, which can produce adipokines [35], peptide hormones, including adiponectin (ACRP30), retinol binding protein-4 (RBP4), and resistin, as well as proinflammatory cytokines, such as interleukin- (IL-) 6 and tumor necrosis factor-α (TNF-α) [36].