EGFR and glioblastoma: Additionally, it has been demonstrated that exogenous endocannabinoids applied at nanomolar concentrations can induce cancer cell proliferation in glioblastoma and lung carcinoma cell lines through activation of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase commonly upregulated in cancer that can activate downstream pro-oncogenic signaling pathways resulting in cancer cell proliferation (26, 27).