Age, BMI, duration of DM, use of insulin, comorbid hyperlipidaemia, comorbid DPN, comorbid DR, comorbid DKD, serum levels of FPG, Scr, BUA and BUN were used as independent variables (see Table 2 for assignments) and whether the patient had comorbid pruritus (assignments: 0 = no, 1 = yes) was used as the dependent variable in a one-way logistic regression analysis. This evidence concerns the gene INS and Pruritus.