TAC1 and type 2 diabetes mellitus: Meanwhile, this study observed the effectiveness of comprehensive care in patients with T2DM complicated by pruritus, and the results showed that satisfaction rate of nursing care, treatment efficiency, post-care improvement in VAS scores, serum substance P, β-EP and INF-γ levels and other mediators of pruritus were better in Group B with integrated nursing intervention than in group A with conventional care only.