ACE2-positive brain microvascular endothelial cells were found in the basal ganglia of COVID-19 and control patients (Kirschenbaum et al., 2021), in the Medulla Oblongata (Meinhardt et al., 2021) and in the frontal cortex predominantly in patients that suffered from dementia or hypertension (Buzhdygan et al., 2020). The gene discussed is ACE2; the disease is hypertensive disorder.