This effect was attributed to the significantly increased transcription of S100A8/A9 in platelets of COVID-19 patients and circulating levels of its protein product MRP8/14, a known pro-inflammatory heterodimer secreted by activated platelets and neutrophils, was also found to correlate with COVID-19 severity (Barrett et al., 2021). This evidence concerns the gene IGKV1D-22 and COVID-19.