TLR4 and TLR9 are highly expressed in M13MDA-435-1 and -3 hybrid breast tumor cells (Fried et al., 2016), while their cultivation in the presence of the TLR4 ligand lipopolysaccharide induces apoptosis in all hybrid clones (Fried et al., 2016). The gene discussed is TLR4; the disease is breast neoplasm.