Another research found that the protein Amuc_1100 derived from the outer membrane of A. muciniphila maintained the integrity of the intestinal barrier by interacting with toll-like receptor 2 (TLR2), thereby alleviating obesity and insulin resistance in HFD-fed mice (Plovier et al., 2017). The gene discussed is TLR2; the disease is obesity due to melanocortin 4 receptor deficiency.