Acetate not only improved the hypothalamic-pituitary-ovarian function of female patients with T2DM by inhibiting histone deacetylase-5 (HDAC5) (Olaniyi et al., 2021a), but also alleviated the testicular dysfunction in male patients with diabetes by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) (Olaniyi et al., 2021b). This evidence concerns the gene PCSK9 and type 2 diabetes mellitus.