The endocytic uptake of IFS-LNC nanocapsule by MG63 cancer cells accelerated the destruction of acidic endosomal vesicles of the nanocapsule and accelerated the release of IFS into the cytoplasm. The apoptosis of OS cells was increased by increasing the expression levels of Caspase-3 and Caspase-9 in MG63 cells. Here, CASP3 is linked to cancer.