Numerous biological processes performed by macrophages are controlled by the mTOR pathway, including metabolism, chemokine and cytokine production, antigen presentation, autophagy and survival (91).The mTOR signaling is associated with the development and progression of many cancers (92, 93), mTOR inhibitors have therapeutic value in a number of cancers in both preclinical and clinical settings (94). The gene discussed is MTOR; the disease is cancer.