The results revealed that the expression of CDC27 is related to the malignancy degree of NB, because CDC27 expression was not only markedly increased in NB and GNB tissues compared with GN tissues (NB+GNB n=96, GN n=25; Figures 1A, B), but also higher in stage 3-4 NB patients than in stage 1-2 NB patients (Figure 1C). This evidence concerns the gene CDC27 and ganglioneuroma.