REN and Insulin resistance: In the male animals, the 8-week feeding with a CAN diet gave rise to many adverse events, as follows: increases in blood pressure and heart rate; insulin resistance; thrombopenia; injuries or abnormalities in renal and cardiac pathology; reduction in plasma testosterone, with a concomitant increase in plasma aldosterone; and increases in the expression of mRNA for renin in the kidney and in plasma concentrations of renin and angiotensin II.