In summation, the cohort described and those in the literature indicate that the rhabdomyolysis in patients with LPIN1 deficiency can be seen in a setting of an inciting factor or when one is not identified; should be monitored by use of either dilutional CK levels or co-monitoring of transaminase levels; treated with high glucose fluids with or without bicarbonate supplement based on laboratory values; monitored for elevated K levels [19] that may lead to arrythmias; and have anti-inflammatory treatment (i.e., dexamethasone) considered for severe case presentations. Here, LPIN1 is linked to hyperinsulinemic hypoglycemia, familial, 4.