The coexpression of MACC1, c-Met, and cyclin D1 has an effect on the survival of ESCC patients, and the coexpression of MACC1 and cyclin D1 and the coexpression of c-Met and cyclin D1 have a significantly poor prognosis (P < 0.05). The gene discussed is MACC1; the disease is esophageal squamous cell carcinoma.