Our further analysis found that the coexpression of three proteins, MACC1, c-Met, and cyclin D1, had an impact on the overall survival of ESCC, which again fully demonstrated that MACC1, c-Met, and cyclin D1 were jointly involved in the occurrence and development of ESCC and had an impact on the patient's survival prognosis. Here, CCND1 is linked to esophageal squamous cell carcinoma.