LPL and hypertriglyceridemia: Primary chylomicronemia is the result of inactivating mutations in both alleles of LPL genes or other genes implicated in other proteins required for LPL activity [9,10] Apolipoprotein C-III is also implicated, its high levels present a risk factor for hypertriglyceridemia which is a the target in treatment by volanesorsen [11].