In this study, some high correlated MSI genes, such as BACH1 in DLBC, CUL3 in DLBC, MAFK in DLBC, MAPK1 in DLBC, MAPK9 in ACC, PIK3CA in DLBC, and PRRT2 in CHOL (correlation coefficient > 0.4), should be focused on. The gene discussed is PIK3CA; the disease is adrenal cortex carcinoma.