This study selected Nrf2 and Nrf2 pathway-related genes to do a systematic analysis in pan-cancer, including ATF4, BACH1, CREBBP, CUL3, EIF2AK3, EP300, FOS, FOSL1, GSK3B, JUN, KEAP1, MAF, MAFF, MAFG, MAFK, MAPK1, MAPK3, MAPK7, MAPK8, MAPK9, NRF2, PIK3CA, PRRT2, and RIT1. The gene discussed is PIK3CA; the disease is cancer.