This study selected Nrf2 and Nrf2 pathway-related genes to do a systematic analysis in pan-cancer, including ATF4, BACH1, CREBBP, CUL3, EIF2AK3, EP300, FOS, FOSL1, GSK3B, JUN, KEAP1, MAF, MAFF, MAFG, MAFK, MAPK1, MAPK3, MAPK7, MAPK8, MAPK9, NRF2, PIK3CA, PRRT2, and RIT1. The gene discussed is PRRT2; the disease is cancer.