As diosmetin has been confirmed to inhibit Akt activation in cancer cells including lung cancer cells and decrease p-AKT/AKT in MI model neonatal rats [29, 30], diosmetin dose-dependent reduced Akt phosphorylation and inhibited the PI3K/Akt pathway in non-small-cell lung cancer cells [20]. The gene discussed is AKT1; the disease is lung carcinoma.