HMGB1 and hematoma: We found that there were significant differences in the expression of P38 MAPK (F = 7.429, p = 0.002), MyD88 (F = 6.973, p = 0.002), HMGB1 (F = 11.753, p < 0.001), and IL-1β (F = 6.821, p = 0.002) around hematoma among the four groups (n = 6 mice/group, Figure 3 and Supplementary Figure 3).