Although the expression of P38 MAPK, HMGB1, and IL-1β around the hematoma increased slightly in mice that received a choline diet when compared with those of mice that received a regular diet at 24 h after ICH, the difference was not statistically significant (all p > 0.05, Figure 3 and Supplementary Figure 3). This evidence concerns the gene HMGB1 and hematoma.