OTX2 and neoplasm: We used bioinformatic analysis to predict that the differentially methylated CpG sites in SST common to all three tumor types (+42 and +44) may be binding sites for the transcription factors RHOXF1, ETS1, GSC, GSC2, DPRX, OTX1, and OTX2. The SST CpG sites +127 and +129 are the binding sites for the transcription factors EBF1 and NR2C2. ETS1 [26] and OTX1 [27] have been verified to be related to the progression of GC.