GSE8511 database analysis result showed that compared to normal tissues, HK2, PFKFB3, SLC2A1, PGK1, PKM2, and LDHA were upregulated, and PGAM1, SLC2A3, and LDHB were downregulated in PCa (Figure 1(a)). This evidence concerns the gene PFKFB3 and posterior cortical atrophy.