NR5A2 and Friedreich ataxia: In the TCGA cohort, the mutation rates of 7 DDR pathways were higher in the PAK7-MT group, which included base excision repair (BER), checkpoint factor (CPF), Fanconi anemia (FA), homologous recombination repair (HRR), mismatch repair (MMR), nucleotide excision repair (NER), and nonhomologous end-joining (NHEJ) (Figure 3D).