As a versatile kinase, PAK7 activates many oncogenic pathways in malignant tumors, such as PI3K/AKT signaling (51–53), SATB1 pathway (54), Egr1/MMP2 pathway (55, 56), GATA1 pathway (57), E47 pathway (58), p65-NFkB/cyclin D1 pathway (59–61), and Raf-1 pathway (62, 63), thereby playing a crucial role in activating the tumor proliferation, invasion, and metastasis and preventing cell apoptosis (53, 64–66). The gene discussed is NFKB1; the disease is cancer.