CD4 and lung adenocarcinoma: OncoSG cohort (24), consisting of east Asian lung adenocarcinomas patients (n = 169) was used to revalidate the CIBERSORT result, which showed significant increase in the CD8+ T cells (0.093 vs. 0.059, P = 0.033), plasma cells (0.167 vs. 0.056, P = 0.015), and activated memory CD4+ T cell (0.081 vs. 0.037,P = 0.019) in PAK7-MT group as compared to the PAK7-WT group (Supplementary Figure 4).