MICA and neoplasm: This review focused on KIR-related alloreactivity, but many other receptors are known to impact NK functions, such as natural cytotoxicity receptors (NCRs) which play an important role in killing tumor cells of different origins including leukemic cells (111): for example, NKG2D, which is involved in tumor cell recognition by binding specific stress-inducible molecules, MICA/B and ULBPs (112).