It is worth noting that KIR/MHC interactions have also largely been described in the genetic prediction of malignancies such as AML (104) or neuroblastoma (116) and outcomes of solid tumors (117), pregnancy disorders (118), or viral disease clearance such as HCV/HBV (119, 120) or HIV (121), highlighting all the potential implications and power of this extraordinary system that is slowly revealing its secrets. This evidence concerns the gene HLA-C and acute myeloid leukemia.