Compared to normal renal tissues, the proportions of T cells CD8, T cells follicular helper, T cells regulatory (Tregs), Macrophages M0 and Macrophages M1 were significantly overexpressed, while B cells naïve, Plasma cells, T cells CD4 naïve, T cells CD4 memory resting, Monocytes, Dendritic cells resting and Mast cells resting decreased in ccRCC (Figure 5B). Here, CD4 is linked to nonpapillary renal cell carcinoma.