ICOS and nonpapillary renal cell carcinoma: We identified 34 immunostimulators (CD27, CD28, CD40, CD40LG, CD48, CD70, CD80, CD86, CD276, CXCR4, ENTPD1, ICOS, IL2RA, IL6, IL6R, KLRC1, KLRK1, LTA, MICB, NT5E, RAET1E, TMIGD2, TNFRSF4, TNFRSF9, TNFRSF17, TNFRSF18, TNFSF4, TNFSF9, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, ULBP1 and TNFRSF8) (Figure 10A) and 15 immunoinhibitors (BTLA, CD96, CD244, CSF1R, CTLA4, HAVCR2, IL10, IL10RB, KDR, LAG3, LGALS9, PDCD1, PDCD1LG2, TGFB1 and TIGIT) (Figure 10B) significantly associated with OIP5 in ccRCC.