OIP5 and inborn error of immunity: Further, GSEA analysis showed that OIP5 was associated with several immune-related signaling pathways, including the homologous recombination signaling pathway (NES = 1.75, P =0.004), autoimmune thyroid disease signaling pathway (NES = -1.68, P = 0.004), primary immunodeficiency signaling pathway (NES = -1.58, P = 0.021), and intestinal immune network for IgA production (NES = -1.54, P = 0.03) (Figure 9).