The upregulation of miR-490 expression levels in MC-derived exosomes stimulated by HCV-E2 and transferred to hepatocellular carcinoma (HCC) cells inhibit tumor metastasis by reducing the activity of the EGFR/AKT/ERK1/2 pathway, thereby suppressing invasion of HCC cells (39). This evidence concerns the gene EGFR and hepatocellular carcinoma.