Xu et al. found that the removal of the oncogene miR-375 from glioma cells by exosomes leads to the continuous activation of the CTGF-EGFR oncogenic pathway, which promoted the multiplication, metastasis, and aggression of glioma (44), indicating that exosomal miR-375 may be a promising glioma biomarker. Here, CCN2 is linked to central nervous system cancer.