Moreover, Nabet et al. (83), found that triggering stromal NOTCH-MYC in breast cancer cells led to an increase in POL3-driven RN7SL1 expression, which resulted in the production of RN7SL1 in stromal exosomes that were not shielded by the RNA-binding protein SRP9/14. The gene discussed is RN7SL1; the disease is breast carcinoma.