They found that in exosomes with miR-21-5p and miR-10b-5p/miR-221-3p/miR-223-3p expression was significantly higher than that of non-HCC patients (84); thus, exosome-encapsulated microRNAs could be used as circulating diagnostic markers for low methemoglobin HCC. Here, HBG2 is linked to hepatocellular carcinoma.