TGFBR3 and neoplasm: Yin et al. (48) demonstrated that in pancreatic ductal adenocarcinoma tissue, M2 macrophage-derived exosomal miR-501-3p inhibited the expression of TGFBR3, a tumor suppressor gene, by activating the transforming growth factor-β signaling pathway, thereby promoting tumor development (48), and possibly providing a new target for the molecular therapy of pancreatic ductal adenocarcinoma.