IFNG and thyroiditis: For example, Cui et al. (36) found that IFN-γ-treated thyroid cell-derived exosomes containing TPO, HSP60, and MHC-II in vitro targeted the activation of dendritic cells, which in turn promoted the expression and release of proinflammatory cytokines IFN-γ, IL-17A, and IL-22 by CD4+ T lymphocytes and inhibited the expression and release of anti-inflammatory cytokines IL-4, IL-10, and TGF-β1, ultimately suppressing thyroiditis (36).