It has also been demonstrated that within exosomally delivered microRNAs in the plasma of patients with systemic lupus erythematosus (SLE) are potential novel TLR7 endogenous ligands that induce plasma cell-like DC (pDC) activation and the production of IFN-α and proinflammatory cytokines (31). This evidence concerns the gene TLR7 and systemic lupus erythematosus.