CD274 and neoplasm: Zhou et al. (49) found that miR-1468-5p encapsulated in exosomes secreted from cervical cancer promoted lymph angiogenesis, upregulated PD-L1 expression, impaired T-cell immunity, directly targeted the SOCS1 promoter in HMBOX1, activated the JAK2/STAT3 pathway in tumor-associated lymphatic endothelial cells (LECs), and enabled cancer cells to evade anticancer immunity.