Xu et al. (50) found that exosome-encapsulated miR-6089 from patients with RA inhibited lipopolysaccharide (LPS)-induced cell proliferation and activation of macrophage-like THP-1 cells and regulated IL-6, IL-29, and TNF-α production by targeting the TLR4 signaling pathway. Here, TLR4 is linked to rheumatoid arthritis.