Moreover, relative to a diagnosis using a TSH threshold of ≥ 4.50 mIU/L, SCH cases diagnosed using criteria 1–5 and the new threshold (≥ 6.50 mIU/L) had significantly higher proportions of TG-Ab-positive and TPO-Ab-positive cases (P < 0.01). The gene discussed is TPO; the disease is spindle cell hemangioma.