In the present study, there are seven crucial genes in T2D hearts according to the gene abundance grades in single event among the top-10 GO events, including Capns1, F3, Mosp1, Tmpress5 in cellular component module, and CAPNS1, FECH, SFXN4, UCP3 in molecular function module. This evidence concerns the gene CAPNS1 and type 2 diabetes mellitus.