Therefore, CAPNS1 gene may serve as a potential biomarker and therapeutic target for the onset, progression and prognostic of cardiovascular syndrome in T2D patients with SARS-CoV-2 infection, and a potential target of anti-SARS-CoV-2 comprehensive therapy, although it remains to be validated by further pre-clinical and prospective clinical studies (40). This evidence concerns the gene CAPNS1 and type 2 diabetes mellitus.