Several of these target genes have been reported to be closely related to the formation, growth and rupture of intracranial aneurysms, including transglutaminase 2 (TGM2), epiregulin (EREG), endothelin-1 (EDN1) and alpha 1 type IV collagen (COL4A1). The gene discussed is TGM2; the disease is Dilatation of the cerebral artery.