For instance, NF-kB inducing kinase, a MAC-dependent activator of non canonical NF-kB signaling, has been recently shown to mediate in an in vivo model allograft vasculopathy, an immune-mediated vascular remodelling consisting in diffuse stenosis affecting the vasculature of solid organ transplant (Qin et al., 2016). Here, NFKB1 is linked to vascular disorder.