BDNF and Anxiety: As the oxido-nitrosative stress and the impairment of the BDNF signal in the brain are also known to mediate the pathogenesis of anxiety (Li et al., 2017; Olugbemide et al., 2021), our findings about the regulatory effect of I3C on oxido-nitrosative stress and the BDNF signal should reveal a possible role of I3C in amelioration of anxiety; however, the fact is that the I3C supplementation did not prevent the CSDS-induced anxiety-like behaviors in mice.