JWH-133 (1 mg/kg i.p.)chronic administration for 30 consecutive days starting on day 30 of tumor growth produced an increase in CB2 (t4 = 2.50, p < 0.0333 unpaired t-test (one-tailed); Figures 6A,B) and TNFα (t4 = 3.568, p < 0.0117 unpaired t-test (one-tailed); Figures 6A,C) protein levels in the OVCAR-5 ectopic xenograft tumors of SCID-SHO female mice relative to the vehicle treated group. This evidence concerns the gene CNR2 and neoplasm.