Additionally, a combination of the three plasma circRNAs can be used as a diagnostic biomarker for hepatocellular carcinoma (AUC: .800) (Wu et al., 2020a); circ-KIAA1244 might represent a novel circulating diagnostic biomarker for gastric cancer (Tang et al., 2018) and circ-RPL15, a plasma circRNA, is a novel biomarker for chronic lymphocytic leukemia (Wu et al., 2020b). This evidence concerns the gene ARFGEF3 and B-cell chronic lymphocytic leukemia.