AKT1 and cancer: The results showed that hsa_circ_0000091, hsa_circ_0067772, and hsa_circ_0000512 are involved in 40 biological signaling pathways (Supplementary Table S3), including some important pathways that are strongly associated with cancer, such as the vascular endothelial growth factor (VEGF)/VEGF receptor, phosphoinositide 3-kinase/Akt, and interleukin 3 (IL-3)–mediated signaling events (Figure 6D).