TNF and psoriasis: Randomized controlled trials (RCT) have found biologic agents, including tumor necrosis factor alpha inhibitors (TNFi) and interleukin inhibitors, to be more effective than placebo and the CSA, methotrexate, in achieving complete or nearly complete skin clearance and maintaining it over a longer period of time in patients with moderate-to-severe psoriasis (Gordon et al., 2006; Mahil et al., 2020).