Given the possible resistance of cancer stem cells to chemotherapeutic agents (Prieto-Vila et al., 2017) and the diminished proliferation inhibition of tumor cells by chemotherapeutic agents, the direct inhibitory effect of TP5 on colon cancer stem cells suggests that the combination of TP5 with chemotherapeutic agents may enhance the therapeutic effect of these chemotherapeutic agents. Here, TMPO is linked to cancer.