Figure 8D showed DNMT1 mRNA expression and ZC3H12D mRNA expression among the copy number variant types of PD-1, PD-L1. Finally, we analyzed the response of HNSCC to chemotherapeutic agents. HNSCC patients in the low risk group were more sensitive to mitomycin C (p = 0.0076), JNK inhibitor VIII (p = 0.0033), AKT inhibitor VIII (p = 0.0038) and rapamycin (p = 0.0079), while less sensitive to epothilone B (p = 0.0017) and OSI 906 (p = 0.00083) compared with the patients in the high risk group, as can be concluded from the half maximal inhibitory concentration (IC50) (Figure 8E). The gene discussed is DNMT1; the disease is head and neck squamous cell carcinoma.