CRTC1 and major depressive disorder: Recently, several studies highlighted the importance of CRTC1 in stress- and inflammation-induced depressive-like behaviors, thus extending our pioneering findings on the role of CRTC1 in MDD (Davis, 2019; Jiang B. et al., 2019; Ni et al., 2019; Liu et al., 2020; Wang et al., 2020; Si et al., 2021).