Mice with a ventromedial hypothalamus (VMH)-specific knockdown of Crtc1 are sensitive to high-fat diet-induced obesity, exhibiting hyperphagia and increased body weight gain.Unlike Crtc1–/– mice, VMH-specific Crtc1 deletion did not affect body weight gain or food intake in normal chow feeding. The gene discussed is CRTC1; the disease is obesity disorder.