CRTC1 and obesity due to melanocortin 4 receptor deficiency: With regard to obesity, further human genetic investigations showed that the CRTC1 locus links fat mass to cardiometabolic diseases (Lu et al., 2016) and that genetic and epigenetic control of CRTC1 transcription affects fat distribution and eating behavior (Booij, 2019; Delacretaz et al., 2019; Rohde et al., 2019; Wang et al., 2021).