Taken together these observations suggest that: (1) the association of CRTC1 locus with obesity markers is stronger when reliable markers of adiposity (such as BF%) are used, (2) it may exist a sex-specific effect, even though, the use of different CRTC1 SNPs and different sample populations (general population versus psychiatric cohorts) complicate the interpretation of these GWAS studies. The gene discussed is CRTC1; the disease is obesity due to melanocortin 4 receptor deficiency.