Moreover, there is evidence in rodents and humans that the CREB-BDNF pathway is also implicated in obesity (Rios, 2013; Lin et al., 2014; Marosi and Mattson, 2014; Xu and Xie, 2016; Amare et al., 2017). The gene discussed is BDNF; the disease is obesity due to melanocortin 4 receptor deficiency.