Of particular importance, increasing evidence suggests that CRTC1 dysregulation may be implicated in the etiopathogenesis of neurodegenerative diseases, such as Huntington’s, Parkinson’s, and Alzheimer’s disease, as well as psychiatric disorders (Boulting et al., 2021), including mood disorders [reviewed in Saura and Cardinaux (2017)]. Here, CRTC1 is linked to psychiatric disorder.