MECP2 and nervous system disorder: Loss of astrocyte complexity is a common pathological feature in many neurological disorders (Burda and Sofroniew, 2014) and, in the field of RTT research, fewer and poorly branched astrocytic ramifications have been described in the dentate gyrus and corpus callosum of Mecp2308/y mouse models as well as in the hippocampus of a conditional mouse, in which Mecp2 has been postnatally inactivated (De Filippis et al., 2012; Nguyen et al., 2012).