Liang et al. (31) suggested that CASC9 promotes esophageal cancer metastasis through the FAK-PI3K/Akt pathway via LAMC2 and that CASC9 stimulates the expression of LAMC2 through CBP-mediated histone acetylation to promote the invasion and metastasis of esophageal cancer. This evidence concerns the gene AKT1 and esophageal cancer.