BCL2 and myelodysplastic syndrome: To exclude the off-target effects of BMS-345541 and further validate that BCL-2 activity drives the survival of CMP-pattern cells but not GMP-pattern MDS cells, we generated xenografts from a patient with GMP-pattern MDS, whose blasts did not show any p65 phosphorylation but showed a high level of BCL-2 expression (Extended Data Fig. 9j).