However, in individuals of European ancestry, this haplotype block (indexed by rs35044562) is in high LD with the LZTFL1 variant rs73064425 (r2 = 0.99) but not the SLC6A20 variant rs2531743 (r2 = 0.02), indicating that these two signals—for severe COVID-19 among infected individuals and for risk of SARS-CoV-2 infection compared with individuals who did not test positive for COVID-19, respectively—are likely independent. Here, LZTFL1 is linked to COVID-19.