Among the 6 replicated variants (in/near LZTFL1, SLC6A20, MHC, ABO, DPP9 and IFNAR2), 4 were significantly (P < 0.05) associated with worse outcomes among infected individuals (in/near LZTFL1, MHC, DPP9 and IFNAR2), while those in ABO and near SLC6A20 were not associated with COVID-19 severity (Extended Data Fig. 1 and Supplementary Table 15). Here, IFNAR2 is linked to COVID-19.