IFNAR2 and infection: The largest human genetics study performed so far included data from 49,562 individuals infected with SARS-CoV-2 and >1.7 million individuals with no record of infection as controls, and identified 13 independent common risk variants12, many located in or near immune-related genes, such as IFNAR2 and CXCR6. Genetic studies of rare variation assayed through exome or genome sequencing have also suggested a role in COVID-19 for genes in the type 1 interferon (IFN) pathway, including TLR713–15.