Comparing normal liver tissue samples (225 patients) and liver hepatocellular carcinoma (LIHC) samples (371 patients), the expression of the genes: RhoA, Rac1, LIMK1, LIMK2, ROCK1, ROCK2, MLCK2, and PAK4 is upregulated in liver cancer (Fig. 7a). Here, PAK4 is linked to liver cancer.