The association between GPD1L and PCs or lysoPC and sarcopenia may involve (1) dysregulation of GPD1L related to decreased PCs and lysoPC from previous lipid biomarkers39,40, or (2) an increase in the glycerol-3 phosphate pathway inducing changes in glycolysis via GPD1L. However, the results of the present study can only be used to suggest a genetic hypothesis; thus, further follow-up studies are needed. Here, GPD1L is linked to sarcopenia.