Genomic variants in several genes that are involved in membrane trafficking have been linked to increased risk for late-onset AD (LOAD), e.g. BIN1, PICALM, CD2AP, CD33, EPHA, RIN3, MEF2C, and PTK2B3–9, providing strong evidence for the role of membrane trafficking in AD pathogenesis. This evidence concerns the gene RIN3 and Alzheimer disease.