Genomic variants in several genes that are involved in membrane trafficking have been linked to increased risk for late-onset AD (LOAD), e.g. BIN1, PICALM, CD2AP, CD33, EPHA, RIN3, MEF2C, and PTK2B3–9, providing strong evidence for the role of membrane trafficking in AD pathogenesis. The gene discussed is CD33; the disease is Alzheimer disease.