The methylation of CpG sites for both CADM1 and MAL have previously been indicated as potential biomarkers in HPV-related cervical intraepithelial neoplasia (CIN) with reports of 78% specificity and 70% sensitivity in women with HRHPV infections for histological CIN3+30. Here, MAL is linked to cervical squamous intraepithelial neoplasia.