CADM1 and infection: For example, if all samples are screened by cytology to filter out all normal samples then CADM1 and HRHPV testing can be added for disease grade diagnosis (between LSIL, HSIL and ASCC) then the predictive value increases to 78.2% (similar to findings in the cervix at 78% specificity and 70% sensitivity in women with HRHPV infections)30.