Exposing human B-ALL cells to ACM did not alter the baseline surface expression of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), the canonical receptor for GAL-9 (Supplementary Fig. 9a); however, ACM induced significant colocalization of GAL-9 and TIM-3 on human B-ALL cells (Supplementary Fig. 9b). Here, LGALS9 is linked to acute lymphoblastic leukemia.