Given the strong induction of GAL-9 in ACM-exposed human B-ALL cell lines, we next mined publicly available databases to examine the expression levels of LGALS9 (the gene encoding GAL-9) and HAVCR2 (the gene encoding TIM-3) in leukemia cells from patients at diagnosis and relapse. Here, LGALS9 is linked to precursor B-cell acute lymphoblastic leukemia.