Similar to human B-ALL cells, we found that ACM also induced chemoresistance to methotrexate and doxorubicin in mB-ALL cell cultures (Supplementary Fig. 12b) and upregulated surface Galectin-9 expression when cultured in ACM (Supplementary Data Fig. 12c, d). The gene discussed is LGALS9; the disease is acute lymphoblastic leukemia.