Furthermore, increases in cell cycle progression in αGAL-9 antibody-treated B-ALL cells exposed to the adipocyte-secretome were concomitant with augmented cPARP and γH2AX activation (DNA damage), as well as Caspase 3 activation and Annexin V/PI positivity (apoptosis). This evidence concerns the gene ANXA5 and precursor B-cell acute lymphoblastic leukemia.