CD4 and neoplasm: As visualized in the UMAP plot of all T cells, reactive T cells, including conventional CD4+ T cells (Tconvs), CD4+ regulatory T cells (Tregs) and CD8+ T cells, were clustered by cell type, and the transcriptome profiles from each sample showed a high degree of overlap, whereas malignant T cells grouped into clear patient-specific clusters, demonstrating the remarkable inter-tumor heterogeneity of malignant T cells (Fig. 1f and Supplementary Fig. 1d and 2a).