TNF and COVID-19: First, a recent meta-analysis [62] of studies conducted in individuals with major depressive disorder following antidepressant treatment, mostly including SSRIs, supports that, overall, antidepressants may be associated with decreased plasma levels of 4 of 16 tested inflammatory mediators, including IL-10, TNF-α, and CCL-2, which are associated with COVID-19 severity [68], as well as IL-6, which is highly correlated with disease mortality [68, 69].