SMPD1 and psychiatric disorder: These results suggest that the acid sphingomyelinase (ASM)/ceramide system may provide a useful framework for better understanding SARS-CoV-2 infection and the repurposing of FIASMA psychotropic medications, especially FIASMA antidepressants that are better tolerated than FIASMA antipsychotics [31–33, 50], against COVID-19 among individuals with psychiatric disorders.