To verify the potential cooperation of BAG3/BAG3R- and SIRPα/CD47-blockades in impairing pancreatic tumor growth, we produced murine orthotopic pancreatic cancer allografts by injecting murine pancreatic cancer cells (mt4–2D) [12, 27] into the pancreata of syngeneic C57BL6 mice (Fig. 1A) and analyzed the effects of a treatment with anti-BAG3 [12] and anti-SIRPα [26] murine monoclonal antibodies on tumor growth. Here, CD47 is linked to familial pancreatic carcinoma.