In this work, we addressed two regulatory pathways, one of which—BAG3/BAG3R—contributes to support the growth of pancreatic carcinoma through the pro-tumor activity of TAMs and CAFs stimulated by BAG3 [2, 3, 10–13], while the other—SIRPα/CD47—is an immune checkpoint that blocks the phagocytosis of neoplastic cells and, notably, the activation of dendritic cells [16–24]. Here, BAG3 is linked to neoplasm.