On the other hand, signal-regulatory protein (SIRP)α (CD172a or SHPS-1), expressed on myeloid cells, upon its binding to neoplastic cell surface CD47 antigen (“don’t eat me” signal) transduces, through its interaction with Src Homology region 2 domain-containing Phosphatases (SHPs), an inhibitory signal, that blocks cancer cell phagocytosis by macrophages and dendritic cell (DC) activation [16–18, 22]. The gene discussed is SIRPA; the disease is cancer.