In the context of the molecules that regulate the interactions between pancreatic carcinoma and its microenvironment, BAG3 attracts interest for some characteristics: the ability to influence both TAMs and CAFs; its specific presence, as a secreted factor, in tumor tissues and not in normal ones; the lack of toxicity of anti-BAG3 antibodies in preclinical treatments, even in the long term [3, 10–15, 29]. Here, BAG3 is linked to neoplasm.