As-T cells generated more IL-8 to promote tumor angiogenesis through its paracrine effect; and IL-8 receptors, C-X-C chemokine receptor type 1 (CXCR1), and CXCR2, are required for As-T cells to induce endothelial cell proliferation, migration, and tube formation, thus enhancing tumor angiogenesis. This evidence concerns the gene CXCR1 and neoplasm.